Testimonials and References
Testimonials
Dr. Lou Dell'Italia MD
Clinical Cardiologist / UAB Professor / VA Researcher
"The TAI test is quickly becoming an essential pillar of our research—not only in cardiology but also in PTSD and other trauma-related conditions with immunological and inflammatory components. Its high sensitivity, specificity, and translational relevance position it as an exceptional tool for clinical use."
Dr. Will Meeks PsyD
Therapist / Clinical Director
"As a clinician, I rely on subjective assessments, my clinical insight, and the client’s presentation. With this test, I now have objective science backed data to support my clinical judgement and insight. It also helps the client to better see and understand the depth of their trauma. This is the tool we have been waiting for!"
Dr. Marc Ó Gríofa MD PhD
Physician / CMO / Ironman
"APX made something that’s usually invisible explicit: I was race-ready, but at a real physiological cost. Having objective molecular data before and after a triathalon transformed how I think about training, tapering, and recovery for endurance performance."
Jeremy Blair
Therapist / CEO Wellstone
"iXpressGenes can help us gain insights that weren’t previously available. The technology helps our teams better connect mental health and primary care in a more integrated, data-driven way. It adds meaningful context to clinical decision-making without adding friction to care."
Dr. Michelle Taylor DO
Medical Director / Ultrarunner
"I joined iXpressGenes as Medical Director because I was compelled by the clinical experience and scientific rigor that led to the development and validation of the Trauma Autoimmune Indicator (TAI) test. When we began working on the APX test, I was confident in the underlying science but initially less certain about its broader applicability—until I saw its potential firsthand.
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As an ultrarunner, I tested myself both before and after completing a 100-mile ultramarathon. The results were striking. Subjectively, I felt better post-race than I had after similar efforts in the past, and the biomarker data supported that experience. That combination of lived experience and objective measurement reinforced my belief in the platform, and I look forward to continuing to use the test as I prepare for my next 100-mile race."
References
MENTAL HEALTH
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Huang, X., Hussain, B., & Chang, J. (2021). Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms. CNS Neurosci Ther, 27(1), 36–47. doi:10.1111/cns.13569. https://www.ncbi.nlm.nih.gov/pubmed/33381913
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HUMAN PERFORMANCE
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Cinelli, M. A., Do, H. T., Miley, G. P., & Silverman, R. B. (2020). Inducible nitric oxide synthase: Regulation, structure, and inhibition. Med Res Rev, 40(1), 158–189. doi:10.1002/med.21599. https://www.ncbi.nlm.nih.gov/pubmed/31192483
Ducharme, J. B., Specht, J. W., Bailly, A. R., Fennel, Z. J., Nava, R. C., Mermier, C. M., . . . Deyhle, M. R. (2025). Training Status Influences Regulation of Muscle and PBMC TLR4 Expression and Systemic Cytokine Responses to Vigorous Endurance Exercise. Med Sci Sports Exerc, 57(4), 767–780. doi:10.1249/MSS.0000000000003618. https://www.ncbi.nlm.nih.gov/pubmed/39625335
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Sankova, M., Nikolenko, V., Achkasov, E., Schamas-Esposel, M., Sankov, A., Orliuk, M., . . . Zharikov, Y. (2025). Connective tissue dysplasia and pathogenetic mechanisms as a factor in impaired musculoskeletal adaptation in youth: a sports medicine review. Sport Sciences for Health. doi:10.1007/s11332-025-01474-y. https://doi.org/10.1007/s11332-025-01474-y
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Smolgovsky, S., Ibeh, U., Tamayo, T. P., & Alcaide, P. (2021). Adding insult to injury - Inflammation at the heart of cardiac fibrosis. Cell Signal, 77, 109828. doi:10.1016/j.cellsig.2020.109828. https://www.ncbi.nlm.nih.gov/pubmed/33166625
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