Transforming the Understanding of Stress-Related Inflammation

Trauma Autoimmune Indicator (TAI™) Test by iXG

What is TAI™?

TAI™ is a lab-developed RNA biomarker panel that quantifies inflammation-related activity associated with chronic stress and trauma exposure.

TAI™ provides objective molecular data that can help contextualize physiological stress responses without relying solely on symptom expression or self-reporting.

No assumptions. No stigma. Just inflammation intelligence.

The Clinical Blind Spot in Stress

& Trauma Care

Symptoms arrive late. Biology begins early.

Traditional behavioral and mental health screening tools rely on patient recall and subjective assessments. Meanwhile, the body’s inflammatory and immune responses to significant stressors may begin long before symptoms appear or are recognized.

TAI™ helps bridge this gap by offering molecular-level insights into inflammation and immune activity associated with both chronic stress and trauma exposure. These data can complement clinical evaluations, providing a biological context to support comprehensive decision-making.

Where screenings evaluate perception, TAI™ quantifies biological activity associated with stress.

The TAI™ Framework

Inflammatory signatures offer a window into stress physiology.

Developed by iXG, a pioneer in RNA-based inflammation diagnostics, TAI™ analyzes expression patterns in four domains associated with significant or prolonged stress:

Inflammatory Regulation: Dysregulation can signal systemic stress response or chronic immune activation.
Immune Activation: Elevated markers may reflect sustained inflammatory load following trauma exposure.
Oxidative Stress / Mitochondrial Strain: Indicates cellular-level fatigue and metabolic disruption often seen in chronic stress conditions.
Blood–Brain Barrier Integrity: Biomarkers correlated with neuroinflammatory processes and central nervous system permeability.

These domains are not diagnostic. They provide objective, biologically relevant data that clinicians may consider when evaluating complex presentations.

Molecular Markers. Clinically Grounded.

TAI™ evaluates a curated panel of RNA transcripts tied to:

Innate and adaptive immune system activity

Pro- and anti-inflammatory signaling pathways

Neuroimmune interactions and CNS stress

Tissue damage response and mitochondrial dysfunction

Each transcript was selected based on its documented role in stress physiology and inflammation.

Results are categorized into interpretable patterns intended to inform, but not replace, clinical judgment.

BUILT FOR CLINICAL INTEGRATION

For Mental Health & Trauma Providers

Adds molecular context to histories, screenings, and patient narratives.

For Primary Care & Pain Medicine

Adds an inflammation-focused data point to support integrative treatment plans in stress-related conditions.

For Functional & Integrative Clinics

Supports personalized protocols for patients experiencing chronic inflammation or fatigue.

For Veterans & High-Stress Professions

Provides objective validation of physiological stress burden in populations underserved by traditional mental health frameworks.

The TAI™ Sreening Process

TAI™ is a laboratory-developed test and is not intended to diagnose, treat, or cure any disease.

The Future of Trauma
Science Is Molecular

As the fields of stress physiology and inflammation research evolve, TAI™ equips providers with a modern, RNA-based toolset.

iXG is redefining what’s possible by bridging molecular biology with real-world clinical needs, helping illuminate how the body responds to significant or prolonged stress.

This is trauma care without guesswork. This is inflammation intelligence.

Download the TAI Booklet