Measure upstream biology. Act with confidence.
The CoreSignals™ Panel measures 22 RNA biomarkers for systemic inflammation using RT-qPCR methodology, transforming biological data into actionable intelligence for wellness, longevity, metabolic, and performance platforms.
Advancing the Understanding of Trauma's Impact on Health
We are developing solutions designed to provide insights into the body's response to stress well before traditional symptoms may appear.
Innovative Biological Research for Earlier Insight
iXpressGenes is advancing the understanding of trauma's impact on health through innovative biological research. We are developing solutions designed to provide insights into the body's response to stress well before traditional symptoms may appear.
Our pioneering Trauma Autoimmune Indicator (TAI) test analyzes RNA biomarkers to reveal connections between mental and physical well-being. We aim to equip healthcare providers with objective data, supporting a more proactive and informed approach to care that seeks to improve long-term wellness outcomes.
CLIA-Certified, CAP-Accredited Laboratory
Huntsville, Alabama
RNA-Based Analysis
Molecular perspective beyond traditional methods
Hidden Patterns Revealed
Biological effects of trauma often not visible through traditional methods
Objective Data
Providing healthcare providers with measurable insights
Earlier Intervention
Address health challenges earlier in the journey
Research Born From Lived Reality
The Origin
On February 10th, Founder Dr. Joe Ng survived an on-campus shooting at UAH. Following the shooting, he noticed a spectrum of resilience among the survivors — and the research began.
Discovery Phase
Years of dedicated research into the biological impact of trauma, discovering biomarkers that provide new understanding of how stress affects the body's systems.
Clinical Application
iXpressGenes now offers pioneering tests including TAI and APX, providing healthcare providers with objective data for more proactive care.
What Drives Us
Our approach is rooted in biology and driven by a commitment to providing a molecular perspective that goes beyond traditional methods.
Science-First Approach
Our work is rooted in biology, analyzing RNA to understand changes in the immune system's response to stress.
Proactive Insights
Moving from reactive to proactive understanding of health, providing insights before traditional symptoms may appear.
Human-Centered Mission
Born from lived reality, our research aims to equip healthcare providers with objective data for better patient outcomes.
Clinical Excellence
Operating in a CAP-accredited laboratory with rigorous quality standards and peer-reviewed scientific foundations.
Static labs explain what exists. RNA signals reveal what the body is actively doing.
Most wellness and clinical programs operate using incomplete snapshots of biology. Traditional biomarkers show what is present at a single moment in time — but fail to explain why outcomes vary, why clients plateau, or how interventions are truly impacting biological function.
The CoreSignals™ Panel introduces a continuous intelligence layer - measuring 22 RNA biomarkers for systemic inflammation to reveal the biological dynamics behind patient responses.
One intelligence platform. Two specialized systems.
CLIA-Certified LaboratoryThe CoreSignals™ Panel is the foundation of our biological intelligence platform - a comprehensive blood test measuring 22 RNA biomarkers for systemic inflammation.
- CLIA-certified, CAP-accredited lab
- CoreSignals™ Panel: 22 RNA biomarkers
- RT-qPCR methodology
- Systemic inflammation profiling
- 5 biomarker categories
- Longitudinal biological tracking
White-Label Mobile Web AppA provider-adopted, white-label mobile web app that delivers your brand directly to patients with personalized dashboards, insights, and optimization plans.
- White-label mobile web app
- Patient-facing dashboards
- Biological scoring & visualizations
- Longitudinal trend tracking
- Provider-customizable insights
- Branded patient engagement
The patient experience that drives engagement
A white-label mobile web app that delivers personalized health insights directly to your patients under your brand.
Personalized Dashboard
Real-time inflammation scores and CoreSignals™ reports tailored to each patient
Longitudinal Tracking
Visual trends that show biological changes over time
Smart Insights
Provider-customizable interventions across sleep, nutrition, stress, and more
Your Brand, Your Patients
White-label solution that strengthens your practice identity
From blood sample to actionable intervention
The CoreSignals™ Panel bridges the gap between molecular biology and clinical decision-making - transforming RNA biomarker data from peripheral blood into interpretable inflammation profiles that support provider optimization strategies.
A single test is a snapshot. Longitudinal intelligence reveals the trend.
The power of biological intelligence is not a one-time report. Continuous measurement validates interventions, uncovers patterns, explains variability, and creates a measurable optimization loop between provider and client.
This is where recurring engagement — and measurable outcomes — are created.
Built for modern wellness providers
iXG delivers biological intelligence frameworks designed to support providers operating in high-engagement, optimization-focused care models.
Functional Medicine
Root-cause analysis with molecular-level inflammatory and metabolic insight to guide personalized protocols.
Weight Loss & GLP-1
Explain plateaus, fatigue, variability in response, inflammatory burden, and metabolic adaptation.
Hormone / TRT
Track inflammatory stress, recovery strain, and optimization response for hormonal interventions.
Performance & Recovery
Measure adaptation, readiness, recovery, and biological stress for elite performance optimization.
Longevity Clinics
Continuous optimization, aging biology, inflammatory intelligence, and proactive monitoring.
IV Therapy
Data-informed personalization and measurable optimization for infusion protocols.
Dr. Mark Gordon
Founder of Millennium Health and world renowned expert in Interventional Endocrinology and Neuroendocrinology, with over 25 years of experience working with veterans, NFL athletes, and civilians suffering from the effects of traumatic brain injury (TBI). Learn more
"Thank you iXpressGenes. Your panel testing for inflammatory markers will add another level of support to Millennium's approach for assessing neurotrauma and treating for recovery. It was inevitable for sure."
The CoreSignals™ Panel: 22 RNA biomarkers for systemic inflammation
Our CLIA-certified, CAP-accredited laboratory uses RT-qPCR (Reverse Transcription Quantitative PCR) to measure gene expression levels in peripheral blood, providing molecular biomarker data to support clinical assessments.
CoreSignals™ Panel Biomarkers
22 gene expression markers across 5 functional categories, measured via peripheral blood sample
Pro-inflammatory Cytokines
Key signals that activate inflammation
Anti-inflammatory / Regulatory
Signals that regulate and resolve inflammation
Inflammasome & Apoptosis
Cellular stress and damage response
Metabolism & Oxidative Stress
Metabolic and energy pathway activity
ECM Remodeling & Innate Sensing
Tissue repair and immune alertness
Why RNA biomarkers matter
Real-Time Biology
RNA reflects active biological processes - not static genetic presence alone.
Upstream Insight
Earlier detection of biological shifts before downstream dysfunction appears.
Dynamic Measurement
Longitudinal tracking reveals biological response over time.
Inflammation is the common biological thread.
Inflammatory signaling impacts metabolic health, recovery, hormonal balance, performance, and longevity. The CoreSignals™ Panel helps providers measure and interpret these biological patterns with precision.
Gene expression measured in peripheral blood via RT-qPCR
Results interpreted in context of clinical evaluation
Serial testing enables longitudinal trend assessment
Important: The CoreSignals™ Panel was developed by iXpressGenes and its performance characteristics determined by our laboratory. This test is performed under CLIA certification for high-complexity clinical laboratory testing. Gene expression results should be interpreted by a qualified healthcare provider in the context of complete clinical evaluation. This test does not diagnose any specific disease or medical condition.
Dr. Lou Dell'Italia MD
Dr. Louis J. Dell'Italia, MD, is Associate Chief of Staff for Research at the Birmingham VA Health Care System and Professor Emeritus at UAB. He is a nationally recognized expert in heart failure and valvular disease, with leading research in myocardial remodeling and inflammation.
"The TAI test is quickly becoming an essential pillar of our research—not only in cardiology but also in PTSD and other trauma-related conditions with immunological and inflammatory components. Its high sensitivity, specificity, and translational relevance position it as an exceptional tool for clinical use."
Advancing Translational Research with RNA Expression Intelligence
From discovery to validated gene-expression panels, iXpressGenes delivers objective molecular endpoints for research, clinical studies, and multi-site programs.
CLIA-Certified. CAP-Accredited. Research-Ready.
iXpressGenes operates a CLIA-certified, CAP-accredited laboratory in Huntsville, Alabama, deploying assays as validated LDTs designed for reproducible cross-site use in research and translational contexts.
From Finalized Gene List to Validated Panel in About Four Weeks
Our streamlined, project-driven development workflow is built to move rapidly from a discovered signature to a deployable gene-expression panel.
Target Definition
Begin with investigator-provided genes, candidate targets, or transcriptomic signatures identified through discovery work.
Assay Design & Bench Work
Translate targets into a focused RT-qPCR or multiplex transcriptional panel designed for robust analytical performance.
QC & Validation
Complete bench validation, quality control, and CLIA/CAP-aligned analytical checks to support reproducibility.
Deployable LDT Output
Deliver a validated panel ready for translational studies, longitudinal research, or multi-site implementation.
Designed for speed without compromising scientific rigor or deployment readiness.
From Whole Transcriptome Discovery to Focused, Scalable Panels
Beyond rapid panel design from investigator-supplied gene lists, iXpressGenes brings deep sequencing and bioinformatics capability to identify reproducible disease- or phenotype-associated RNA fingerprints.
RNA-Seq Discovery
Whole-transcriptome sequencing on selected populations or phenotype-defined subsets.
Bioinformatic Analysis
Rigorous QC, alignment, differential expression, pathway analysis, and marker selection.
Signature Identification
Extraction of reproducible RNA fingerprints associated with disease states or intervention response.
Panel Operationalization
Conversion into focused RT-qPCR or multiplex panels for scalable testing and objective endpoints.
Rigorous, Reproducible, and Built to Scale
iXpressGenes combines next-generation sequencing, standardized RNA quality control, and proven bioinformatic workflows to discover, validate, and operationalize multi-marker expression signatures.
Core Analytical Capabilities
- RNA quality control and standardized preprocessing
- Read alignment and transcript quantification
- Differential expression analysis
- Functional and pathway annotation
- Multi-marker signature extraction
Research Outcomes Enabled
- Discovery of novel, reproducible expression fingerprints
- Validation across additional samples and cohorts
- Translation into deployable gene-expression panels
- Support for broader research or clinical implementation
- Objective endpoints for translational programs
Demonstrated Across a Broad Translational Research Landscape
Applied work across behavioral, neurological, inflammatory, and cardiometabolic research domains, with flexibility for emerging translational areas.
Mental Health & Inflammation
Objective measurement of inflammation reduction and transcriptomic change in cognitive behavioral therapy, vagal or autonomic modulation, breathwork, and nutritional intervention studies.
Obsessive-Compulsive Disorder
Support for deep sequencing, bioinformatic analysis, TAI testing, and the development of OCD-specific panels derived from identified RNA fingerprints.
TBI & Neurodegeneration
Development of panels targeting neuroinflammatory pathways, blood-brain barrier integrity, inflammasome activation, and axonal injury-related biology.
Cardiometabolic & Endocrine
Transcriptional readouts aligned to inflammatory and metabolic biology in studies related to cardiac risk, hypertension, diabetes, and related endpoints.
Additional documented applications include substance-use disorders, chronic pain, autoimmune disease, sleep disorders, and human performance.
Built for Collaboration Across Academic, Government, and Commercial Research
iXpressGenes partners with commercial entities, academic institutions, and government organizations to design, validate, and deploy transcriptional panels that fit real research programs.
Our model supports collaboration from discovery through validation and deployment, making it possible to move from hypothesis generation to practical molecular endpoints within a single integrated workflow.
What Sets iXG Apart in Translational RNA Research
RNA-First
Focused on upstream biological insight through peripheral blood gene-expression measurement.
~4 Weeks
Accelerated pathway from finalized targets to analytically validated, deployable panels.
End-to-End
Discovery, validation, and deployment capability under one integrated framework.
Let's build the future of biological intelligence together.
Connect with iXpressGenes to explore provider partnerships, platform opportunities, research collaboration, or biological intelligence deployment.